The San Francisco 49ers have determined tight end George Kittle as “out” this week against the New York Giants.

Along with Kittle being sidelined, San Francisco will be without starting QB Jimmy Garoppolo and WR Deebo Samuel once again.

Backup tight end Jordan Reed will fill in for Kittle again, and he stepped up with seven catches for 50 yards and two touchdowns last week.

Reed will be needed as a safety blanket for backup QB Nick Mullens, so he’ll have good fantasy production against the Giants.